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 Diagnostic Medicine


Reconstructing perceived faces from brain activations with deep adversarial neural decoding

Neural Information Processing Systems

Here, we present a novel approach to solve the problem of reconstructing perceived stimuli from brain responses by combining probabilistic inference with deep learning. Our approach first inverts the linear transformation from latent features to brain responses with maximum a posteriori estimation and then inverts the nonlinear transformation from perceived stimuli to latent features with adversarial training of convolutional neural networks. We test our approach with a functional magnetic resonance imaging experiment and show that it can generate state-of-the-art reconstructions of perceived faces from brain activations.



A Statistical Recurrent Model on the Manifold of Symmetric Positive Definite Matrices

Neural Information Processing Systems

In a number of disciplines, the data (e.g., graphs, manifolds) to be analyzed are non-Euclidean in nature. Geometric deep learning corresponds to techniques that generalize deep neural network models to such non-Euclidean spaces. Several recent papers have shown how convolutional neural networks (CNNs) can be extended to learn with graph-based data. In this work, we study the setting where the data (or measurements) are ordered, longitudinal or temporal in nature and live on a Riemannian manifold -- this setting is common in a variety of problems in statistical machine learning, vision and medical imaging. We show how recurrent statistical recurrent network models can be defined in such spaces. We give an efficient algorithm and conduct a rigorous analysis of its statistical properties. We perform extensive numerical experiments demonstrating competitive performance with state of the art methods but with significantly less number of parameters. We also show applications to a statistical analysis task in brain imaging, a regime where deep neural network models have only been utilized in limited ways.


0b8aff0438617c055eb55f0ba5d226fa-Supplemental.pdf

Neural Information Processing Systems

Inthis supplemental material, wefirst present thedetailed networkarchitecture andparameters of the proposed approach in Sec. A. We further provide more analysis of the proposed method and ablation studies in Sec. B. Section C shows some qualitative results for potential applications of the proposed approach on medical imaging and imaging in astronomy. Figure 6: Illustration of learned deep features.(a) The blurry input and ground truth are shown in Figure 1(a)-(b). However, on may actually wonder whether the feature extraction network acts as a denoiser, leading to the observed robustness of the proposed method to various noise levels.


Sparse Bayesian Deep Functional Learning with Structured Region Selection

Zhu, Xiaoxian, Li, Yingmeng, Ma, Shuangge, Wu, Mengyun

arXiv.org Machine Learning

In modern applications such as ECG monitoring, neuroimaging, wearable sensing, and industrial equipment diagnostics, complex and continuously structured data are ubiquitous, presenting both challenges and opportunities for functional data analysis. However, existing methods face a critical trade-off: conventional functional models are limited by linearity, whereas deep learning approaches lack interpretable region selection for sparse effects. To bridge these gaps, we propose a sparse Bayesian functional deep neural network (sBayFDNN). It learns adaptive functional embeddings through a deep Bayesian architecture to capture complex nonlinear relationships, while a structured prior enables interpretable, region-wise selection of influential domains with quantified uncertainty. Theoretically, we establish rigorous approximation error bounds, posterior consistency, and region selection consistency. These results provide the first theoretical guarantees for a Bayesian deep functional model, ensuring its reliability and statistical rigor. Empirically, comprehensive simulations and real-world studies confirm the effectiveness and superiority of sBayFDNN. Crucially, sBayFDNN excels in recognizing intricate dependencies for accurate predictions and more precisely identifies functionally meaningful regions, capabilities fundamentally beyond existing approaches.


Anti-causal domain generalization: Leveraging unlabeled data

Saengkyongam, Sorawit, Gamella, Juan L., Miller, Andrew C., Peters, Jonas, Meinshausen, Nicolai, Heinze-Deml, Christina

arXiv.org Machine Learning

The problem of domain generalization concerns learning predictive models that are robust to distribution shifts when deployed in new, previously unseen environments. Existing methods typically require labeled data from multiple training environments, limiting their applicability when labeled data are scarce. In this work, we study domain generalization in an anti-causal setting, where the outcome causes the observed covariates. Under this structure, environment perturbations that affect the covariates do not propagate to the outcome, which motivates regularizing the model's sensitivity to these perturbations. Crucially, estimating these perturbation directions does not require labels, enabling us to leverage unlabeled data from multiple environments. We propose two methods that penalize the model's sensitivity to variations in the mean and covariance of the covariates across environments, respectively, and prove that these methods have worst-case optimality guarantees under certain classes of environments. Finally, we demonstrate the empirical performance of our approach on a controlled physical system and a physiological signal dataset.