Conformal selection (CS) uses calibration data to identify test inputs whose unobserved outcomes are likely to satisfy a pre-specified minimal quality requirement, while controlling the false discovery rate (FDR). Existing methods fix the target FDR level before observing data, which prevents the user from adapting the balance between number of selected test inputs and FDR to downstream needs and constraints based on the available data. For example, in genomics or neuroimaging, researchers often inspect the distribution of test statistics, and decide how aggressively to pursue candidates based on observed evidence strength and available follow-up resources. To address this limitation, we introduce {post-hoc CS} (PH-CS), which generates a path of candidate selection sets, each paired with a data-driven false discovery proportion (FDP) estimate. PH-CS lets the user select any operating point on this path by maximizing a user-specified utility, arbitrarily balancing selection size and FDR. Building on conformal e-variables and the e-Benjamini-Hochberg (e-BH) procedure, PH-CS is proved to provide a finite-sample post-hoc reliability guarantee whereby the ratio between estimated FDP level and true FDP is, on average, upper bounded by $1$, so that the average estimated FDP is, to first order, a valid upper bound on the true FDR. PH-CS is extended to control quality defined in terms of a general risk. Experiments on synthetic and real-world datasets demonstrate that, unlike CS, PH-CS can consistently satisfy user-imposed utility constraints while producing reliable FDP estimates and maintaining competitive FDR control.

CT scans help a museum examine mummified remains that were sitting in its collections for half a century. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Multiple mummy specimens have been stored in the museum since it opened in 1965. Breakthroughs, discoveries, and DIY tips sent six days a week. Not every mummy is treated equally.

Clinical decision-making often involves selecting tests that are costly, invasive, or time-consuming, motivating individualized, sequential strategies for what to measure and when to stop ascertaining. We study the problem of learning cost-optimal sequential decision policies from retrospective data, where test availability depends on prior results, inducing informative missingness. Under a sequential missing-at-random mechanism, we develop a doubly robust Q-learning framework for estimating optimal policies. The method introduces path-specific inverse probability weights that account for heterogeneous test trajectories and satisfy a normalization property conditional on the observed history. By combining these weights with auxiliary contrast models, we construct orthogonal pseudo-outcomes that enable unbiased policy learning when either the acquisition model or the contrast model is correctly specified. We establish oracle inequalities for the stage-wise contrast estimators, along with convergence rates, regret bounds, and misclassification rates for the learned policy. Simulations demonstrate improved cost-adjusted performance over weighted and complete-case baselines, and an application to a prostate cancer cohort study illustrates how the method reduces testing cost without compromising predictive accuracy.

Deep learning underpins a wide range of applications in MRI, including reconstruction, artifact removal, and segmentation. However, progress has been driven largely by public datasets focused on brain and knee imaging, shaping how models are trained and evaluated. As a result, careful studies of the reliability of these models across diverse anatomical settings remain limited. In this work, we introduce MosaicMRI, a large and diverse collection of fully sampled raw musculoskeletal (MSK) MR measurements designed for training and evaluating machine-learning-based methods. MosaicMRI is the largest open-source raw MSK MRI dataset to date, comprising 2,671 volumes and 80,156 slices. The dataset offers substantial diversity in volume orientation (e.g., axial, sagittal), imaging contrasts (e.g., PD, T1, T2), anatomies (e.g., spine, knee, hip, ankle, and others), and numbers of acquisition coils. Using VarNet as a baseline for accelerated reconstruction task, we perform a comprehensive set of experiments to study scaling behavior with respect to both model capacity and dataset size. Interestingly, models trained on the combined anatomies significantly outperform anatomy-specific models in low-sample regimes, highlighting the benefits of anatomical diversity and the presence of exploitable cross-anatomical correlations. We further evaluate robustness and cross-anatomy generalization by training models on one anatomy (e.g., spine) and testing them on another (e.g., knee). Notably, we identify groups of body parts (e.g., foot and elbow) that generalize well with each other, and highlight that performance under domain shifts depends on both training set size, anatomy, and protocol-specific factors.

Machine learning competitions (MLCs) play a pivotal role in advancing artificial intelligence (AI) by fostering innovation, skill development, and practical problem-solving. This study provides a comprehensive analysis of major competition platforms such as Kaggle and Zindi, examining their workflows, evaluation methodologies, and reward structures. It further assesses competition quality, participant expertise, and global reach, with particular attention to demographic trends among top-performing competitors. By exploring the motivations of competition hosts, this paper underscores the significant role of MLCs in shaping AI development, promoting collaboration, and driving impactful technological progress. Furthermore, by combining literature synthesis with platform-level data analysis and practitioner insights a comprehensive understanding of the MLC ecosystem is provided. Moreover, the paper demonstrates that MLCs function at the intersection of academic research and industrial application, fostering the exchange of knowledge, data, and practical methodologies across domains. Their strong ties to open-source communities further promote collaboration, reproducibility, and continuous innovation within the broader ML ecosystem. By shaping research priorities, informing industry standards, and enabling large-scale crowdsourced problem-solving, these competitions play a key role in the ongoing evolution of AI. The study provides insights relevant to researchers, practitioners, and competition organizers, and includes an examination of the future trajectory and sustained influence of MLCs on AI development.

Accurate classification requires not only high predictive accuracy but also well-calibrated confidence estimates. Yet, modern deep neural networks (DNNs) are often overconfident, primarily due to overfitting on the negative log-likelihood (NLL). While focal loss variants alleviate this issue, they typically reduce accuracy, revealing a persistent trade-off between calibration and predictive performance. Motivated by the complementary strengths of generative and discriminative classifiers, we propose Generative Cross-Entropy (GCE), which maximizes $p(x|y)$ and is equivalent to cross-entropy augmented with a class-level confidence regularizer. Under mild conditions, GCE is strictly proper. Across CIFAR-10/100, Tiny-ImageNet, and a medical imaging benchmark, GCE improves both accuracy and calibration over cross-entropy, especially in the long-tailed scenario. Combined with adaptive piecewise temperature scaling (ATS), GCE attains calibration competitive with focal-loss variants without sacrificing accuracy.

Tensor-valued data arise naturally in multidimensional signal and imaging problems, such as biomedical imaging. When incorporated into generalized linear models (GLMs), naive vectorization can destroy their multi-way structure and lead to high-dimensional, ill-posed estimation. To address this challenge, Low Separation Rank (LSR) decompositions reduce model complexity by imposing low-rank multilinear structure on the coefficient tensor. A representative approach for estimating LSR-based tensor GLMs (LSR-TGLMs) is the Low Separation Rank Tensor Regression (LSRTR) algorithm, which adopts block coordinate descent and enforces orthogonality of the factor matrices through repeated QR-based projections. However, the repeated projection steps can be computationally demanding and slow convergence. Motivated by the need for scalable estimation and classification from such data, we propose LSRTR-M, which incorporates Muon (MomentUm Orthogonalized by Newton-Schulz) updates into the LSRTR framework. Specifically, LSRTR-M preserves the original block coordinate scheme while replacing the projection-based factor updates with Muon steps. Across synthetic linear, logistic, and Poisson LSR-TGLMs, LSRTR-M converges faster in both iteration count and wall-clock time, while achieving lower normalized estimation and prediction errors. On the Vessel MNIST 3D task, it further improves computational efficiency while maintaining competitive classification performance.

Quasi-experimental evaluations are central for generating real-world causal evidence and complementing insights from randomized trials. The regression discontinuity design (RDD) is a quasi-experimental design that can be used to estimate the causal effect of treatments that are assigned based on a running variable crossing a threshold. Such threshold-based rules are ubiquitous in healthcare, where predictive and prognostic biomarkers frequently guide treatment decisions. However, standard RD estimators rely on complete outcome data, an assumption often violated in time-to-event analyses where censoring arises from loss to follow-up. To address this issue, we propose a nonparametric approach that leverages doubly robust censoring corrections and can be paired with existing RD estimators. Our approach can handle multiple survival endpoints, long follow-up times, and covariate-dependent variation in survival and censoring. We discuss the relevance of our approach across multiple areas of applications and demonstrate its usefulness through simulations and the prostate component of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial where our new approach offers several advantages, including higher efficiency and robustness to misspecification. We have also developed an open-source software package, $\texttt{rdsurvival}$, for the $\texttt{R}$ language.

Vision transformers (ViT) rely on attention mechanism to weigh input features, and therefore attention scores have naturally been considered as explanations for its decision-making process. However, attention scores are almost always non-zero, resulting in noisy and diffused attention maps and limiting interpretability. Can we quantify uncertainty measures of attention scores and obtain regularized attention scores? To this end, we consider attention scores of ViT in a statistical framework where independent noise would lead to insignificant yet non-zero scores. Leveraging statistical learning techniques, we introduce the bootstrapping for attention scores which generates a baseline distribution of attention scores by resampling input features. Such a bootstrap distribution is then used to estimate significances and posterior probabilities of attention scores. In natural and medical images, the proposed \emph{Attention Regularization} approach demonstrates a straightforward removal of spurious attention arising from noise, drastically improving shrinkage and sparsity. Quantitative evaluations are conducted using both simulation and real-world datasets. Our study highlights bootstrapping as a practical regularization tool when using attention scores as explanations for ViT. Code available: https://github.com/ncchung/AttentionRegularization

In federated healthcare systems, Federated Class-Incremental Learning (FCIL) has emerged as a key paradigm, enabling continuous adaptive model learning among distributed clients while safeguarding data privacy. However, in practical applications, data across agent nodes within the distributed framework often exhibits non-independent and identically distributed (non-IID) characteristics, rendering traditional continual learning methods inapplicable. To address these challenges, this paper covers more comprehensive incremental task scenarios and proposes a dynamic memory allocation strategy for exemplar storage based on the data replay mechanism. This strategy fully taps into the inherent potential of data heterogeneity, while taking into account the performance fairness of all participating clients, thereby establishing a balanced and adaptive solution to mitigate catastrophic forgetting. Unlike the fixed allocation of client exemplar memory, the proposed scheme emphasizes the rational allocation of limited storage resources among clients to improve model performance. Furthermore, extensive experiments are conducted on three medical image datasets, and the results demonstrate significant performance improvements compared to existing baseline models.